[HTML][HTML] Hepcidin, a urinary antimicrobial peptide synthesized in the liver

CH Park, EV Valore, AJ Waring, T Ganz - Journal of biological chemistry, 2001 - ASBMB
Cysteine-rich antimicrobial peptides are abundant in animal and plant tissues involved in
host defense. In insects, most are synthesized in the fat body, an organ analogous to the
liver of vertebrates. From human urine, we characterized a cysteine-rich peptide with three
forms differing by amino-terminal truncation, and we named it hepcidin (Hepc) because of its
origin in the liver and its antimicrobial properties. Two predominant forms, Hepc20 and
Hepc25, contained 20 and 25 amino acid residues with all 8 cysteines connected by …