[HTML][HTML] Novel (Rp)-cAMPS Analogs as Tools for Inhibition of cAMP-kinase in Cell Culture: BASAL cAMP-KINASE ACTIVITY MODULATES INTERLEUKIN-1β ACTION …
Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure
cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene
expression, shape change, apoptosis, DNA replication, and protein phosphorylation in intact
cells. These differences were related to different abilities of the analogs to stabilize the
holoenzyme form relative to the dissociated form of cAMP kinase type I and II.(Rp)-8-Br-
cAMPS and (Rp)-8-Cl-cAMPS were the most potent cAMP antagonists for isolated type I …
cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene
expression, shape change, apoptosis, DNA replication, and protein phosphorylation in intact
cells. These differences were related to different abilities of the analogs to stabilize the
holoenzyme form relative to the dissociated form of cAMP kinase type I and II.(Rp)-8-Br-
cAMPS and (Rp)-8-Cl-cAMPS were the most potent cAMP antagonists for isolated type I …