PAPP-A: a possible pathogenic link to the instability of atherosclerotic plaque
X Li, Q Liu, T Zhou, S Zhao, S Zhou - Medical hypotheses, 2008 - Elsevier
The rupture of coronary atherosclerotic plaque and subsequent thrombus formation are
major events underlying acute coronary syndromes (ACS). Pregnancy associated plasma
protein A (PAPP-A) is a member of the metzincin superfamily of metalloproteinases
originally identified in the serum of pregnant women. Recent studies indicate that ACS is
associated with elevated serum concentrations of PAPP-A. PAPP-A level is not only a
marker of plaque instability favoring the progression to myocardial infarction, but is indicative …
major events underlying acute coronary syndromes (ACS). Pregnancy associated plasma
protein A (PAPP-A) is a member of the metzincin superfamily of metalloproteinases
originally identified in the serum of pregnant women. Recent studies indicate that ACS is
associated with elevated serum concentrations of PAPP-A. PAPP-A level is not only a
marker of plaque instability favoring the progression to myocardial infarction, but is indicative …