Relationship between pregnancy-associated plasma protein-A and lung cancer
I Bulut, E Gulcan, A Coskun, A Ciftci… - The American journal of …, 2009 - Elsevier
Background Pregnancy-associated plasma protein-A (PAPP-A) has insulin-like growth factor
(IGF)-dependent IGFBP-4 protease activity and plays an important role in amplifying local
IGF-1 activity in wound healing, vascular repair, and bone remodeling. We postulated that
PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer.
Therefore, we determined the levels of PAPP-A in patients with lung cancer and their
possible clinical significance. Methods The study population consisted of 83 patients with …
(IGF)-dependent IGFBP-4 protease activity and plays an important role in amplifying local
IGF-1 activity in wound healing, vascular repair, and bone remodeling. We postulated that
PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer.
Therefore, we determined the levels of PAPP-A in patients with lung cancer and their
possible clinical significance. Methods The study population consisted of 83 patients with …