Interventions for preventing the progression of autosomal dominant polycystic kidney disease
D Bolignano, SC Palmer, M Ruospo… - Cochrane Database …, 2015 - cochranelibrary.com
Cochrane Database of Systematic Reviews, 2015•cochranelibrary.com
Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited disorder causing kidney disease. Current clinical management of ADPKD focuses
primarily on symptom control and reducing associated complications, particularly
hypertension. In recent years, improved understanding of molecular and cellular
mechanisms involved in kidney cyst growth and disease progression has resulted in new
pharmaceutical agents to target disease pathogenesis to prevent progressive disease …
inherited disorder causing kidney disease. Current clinical management of ADPKD focuses
primarily on symptom control and reducing associated complications, particularly
hypertension. In recent years, improved understanding of molecular and cellular
mechanisms involved in kidney cyst growth and disease progression has resulted in new
pharmaceutical agents to target disease pathogenesis to prevent progressive disease …
Background
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder causing kidney disease. Current clinical management of ADPKD focuses primarily on symptom control and reducing associated complications, particularly hypertension. In recent years, improved understanding of molecular and cellular mechanisms involved in kidney cyst growth and disease progression has resulted in new pharmaceutical agents to target disease pathogenesis to prevent progressive disease.
Objectives
We aimed to evaluate the effects of interventions for preventing ADPKD progression on kidney function, kidney endpoints, kidney structure, patient‐centred endpoints (such as cardiovascular events, sudden death, all‐cause mortality, hospitalisations, BP control, quality of life, and kidney pain), as well as the general and specific adverse effects related to their use.
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