Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain
SK Tschirner, F Gutzki, EH Schneider, R Seifert… - Journal of the …, 2016 - Elsevier
Lesch–Nyhan syndrome (LNS) is characterized by uric acid overproduction and severe
neurobehavioral symptoms, such as recurrent self-mutilative behavior. To learn more about
the pathophysiology of the disease, we quantified neurotransmitters and their metabolites in
the cerebral hemisphere, cerebellum and the medulla oblongata of HPRT knockout mice, an
animal model for LNS, in comparison to the corresponding wild-type. Our analyses included
l-glutamate, 4-aminobutanoic acid (GABA), acetylcholine, serotonin, 5-hydroxyindoleacetic …
neurobehavioral symptoms, such as recurrent self-mutilative behavior. To learn more about
the pathophysiology of the disease, we quantified neurotransmitters and their metabolites in
the cerebral hemisphere, cerebellum and the medulla oblongata of HPRT knockout mice, an
animal model for LNS, in comparison to the corresponding wild-type. Our analyses included
l-glutamate, 4-aminobutanoic acid (GABA), acetylcholine, serotonin, 5-hydroxyindoleacetic …
