[HTML][HTML] TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc
TT Tsai, KG Danielson, A Guttapalli, E Oguz… - Journal of Biological …, 2006 - ASBMB
The nucleus pulposus is an aggrecan-rich hydrated tissue that permits the intervertebral disc
to resist compressive loads. Adaptation to loading is achieved through an elevation in disc
osmolarity mediated by the numerous charged glycosoaminoglycan side chains of the
aggrecan molecule. The goal of this investigation was to determine the functional role of the
osmo-regulatory protein, TonEBP, in cells of the nucleus pulposus. We found that TonEBP
and its downstream target genes were robustly expressed in the tissues of the disc. Above …
to resist compressive loads. Adaptation to loading is achieved through an elevation in disc
osmolarity mediated by the numerous charged glycosoaminoglycan side chains of the
aggrecan molecule. The goal of this investigation was to determine the functional role of the
osmo-regulatory protein, TonEBP, in cells of the nucleus pulposus. We found that TonEBP
and its downstream target genes were robustly expressed in the tissues of the disc. Above …