Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack

Y Enomoto, K Orihara, T Takamasu, A Matsuda… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Epidermal growth factor receptor ligands, such as epidermal growth factor
(EGF) and amphiregulin, may play key roles in tissue remodeling in asthma. However, the
kinetics of EGF and amphiregulin secretion in the airway after an acute asthma attack and
the effect of prolonged airway exposure to these ligands on airway remodeling are
unknown. OBJECTIVE: To measure the EGF and amphiregulin concentrations in sputa
obtained from patients with asthma under various conditions, and to examine the effects of …