Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
R Polosa, SM Puddicombe, MT Krishna… - Journal of allergy and …, 2002 - Elsevier
Background: The c-erbB family of receptor tyrosine kinases act in a combinatorial fashion to
regulate cell behavior. Disturbances in this system have been associated with neoplastic
and inflammatory diseases. Objectives: Although expression of the epidermal growth factor
receptor (EGFR; c-erbB1) is increased in the bronchial epithelium in asthma, there is no
information on expression of other members of the c-erbB receptor and ligand family that
can modulate EGFR function. Methods: Immunohistochemistry was used to compare …
regulate cell behavior. Disturbances in this system have been associated with neoplastic
and inflammatory diseases. Objectives: Although expression of the epidermal growth factor
receptor (EGFR; c-erbB1) is increased in the bronchial epithelium in asthma, there is no
information on expression of other members of the c-erbB receptor and ligand family that
can modulate EGFR function. Methods: Immunohistochemistry was used to compare …