Mucus hypersecretion in asthma: causes and effects
CM Evans, K Kim, MJ Tuvim… - Current opinion in …, 2009 - journals.lww.com
Markedly upregulated production of MUC5AC together with stimulated secretion leads to
airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may
be possible to selectively inhibit MUC5AC production without impairing airway function. The
precise roles of mucin hypersecretion in asthma symptoms such as dyspnea and cough and
in physiologic phenomena such as airway hyperresponsiveness remain to be defined.
airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may
be possible to selectively inhibit MUC5AC production without impairing airway function. The
precise roles of mucin hypersecretion in asthma symptoms such as dyspnea and cough and
in physiologic phenomena such as airway hyperresponsiveness remain to be defined.
Summary
Markedly upregulated production of MUC5AC together with stimulated secretion leads to airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may be possible to selectively inhibit MUC5AC production without impairing airway function. The precise roles of mucin hypersecretion in asthma symptoms such as dyspnea and cough and in physiologic phenomena such as airway hyperresponsiveness remain to be defined.
Lippincott Williams & Wilkins