[HTML][HTML] ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli
AW Boots, M Hristova, DI Kasahara… - Journal of Biological …, 2009 - ASBMB
Activation of the NADPH oxidase homolog dual oxidase 1 (DUOX1) within the airway
epithelium represents a key mechanism of innate airway host defense, through enhanced
production of H 2 O 2, which mediates cellular signaling pathways that regulate the
production of various inflammatory mediators. Production of the CXC chemokine interleukin
(IL)-8/CXCL8 forms a common epithelial response to many diverse stimuli, including
bacterial and viral triggers, environmental oxidants, and other biological mediators …
epithelium represents a key mechanism of innate airway host defense, through enhanced
production of H 2 O 2, which mediates cellular signaling pathways that regulate the
production of various inflammatory mediators. Production of the CXC chemokine interleukin
(IL)-8/CXCL8 forms a common epithelial response to many diverse stimuli, including
bacterial and viral triggers, environmental oxidants, and other biological mediators …