Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and …
V Lelievre, G Favrais, C Abad, H Adle-Biassette, Y Lu… - Peptides, 2007 - Elsevier
In 1970, Drs. Said and Mutt isolated a novel peptide from porcine intestinal extracts with
powerful vasoactive properties, and named it vasoactive intestinal peptide (VIP). Since then,
the biological actions of VIP in the gut as well as its signal transduction pathways have been
extensively studied. A variety of in vitro and in vivo studies have indicated that VIP,
expressed in intrinsic non-adrenergic non-cholinergic (NANC) neurons, is a potent regulator
of gastrointestinal (GI) motility, water absorption and ion flux, mucus secretion and immune …
powerful vasoactive properties, and named it vasoactive intestinal peptide (VIP). Since then,
the biological actions of VIP in the gut as well as its signal transduction pathways have been
extensively studied. A variety of in vitro and in vivo studies have indicated that VIP,
expressed in intrinsic non-adrenergic non-cholinergic (NANC) neurons, is a potent regulator
of gastrointestinal (GI) motility, water absorption and ion flux, mucus secretion and immune …