Characterization of endothelin-converting enzyme-2: Implication for a role in the nonclassical processing of regulatory peptides
N Mzhavia, H Pan, FY Che, LD Fricker… - Journal of Biological …, 2003 - jbc.org
Most neuroendocrine peptides are generated by proteolysis of the precursors at basic
residue cleavage sites. Prohormone convertases belonging to the subtilisin family of serine
proteases are primarily responsible for processing at these" classical sites." In addition to the
classical cleavages, a subset of bioactive peptides is generated by processing at"
nonclassical" sites. The proteases responsible for these cleavages have not been well
explored. Members of several metalloprotease families have been proposed to be involved …
residue cleavage sites. Prohormone convertases belonging to the subtilisin family of serine
proteases are primarily responsible for processing at these" classical sites." In addition to the
classical cleavages, a subset of bioactive peptides is generated by processing at"
nonclassical" sites. The proteases responsible for these cleavages have not been well
explored. Members of several metalloprotease families have been proposed to be involved …
