[HTML][HTML] Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide (Aβ); retards Aβ aggregation, deposition, fibril formation; and inhibits cytotoxicity
J Hu, A Igarashi, M Kamata, H Nakagawa - Journal of Biological Chemistry, 2001 - ASBMB
We have demonstrated that the angiotensin-converting enzyme (ACE) genotype is
associated with Alzheimer's disease (AD) in the Japanese population (1). To determine why
ACE affects susceptibility to AD, we examined the effect of purified ACE on aggregation of
the amyloid β-peptide (Aβ) in vitro. Surprisingly, ACE was found to significantly inhibit Aβ
aggregation in a dose response manner. The inhibition of aggregation was specifically
blocked by preincubation of ACE with an ACE inhibitor, lisinopril. ACE was confirmed to …
associated with Alzheimer's disease (AD) in the Japanese population (1). To determine why
ACE affects susceptibility to AD, we examined the effect of purified ACE on aggregation of
the amyloid β-peptide (Aβ) in vitro. Surprisingly, ACE was found to significantly inhibit Aβ
aggregation in a dose response manner. The inhibition of aggregation was specifically
blocked by preincubation of ACE with an ACE inhibitor, lisinopril. ACE was confirmed to …