Unresolved questions from the analysis of mice lacking MCU expression
E Murphy, X Pan, T Nguyen, J Liu… - Biochemical and …, 2014 - Elsevier
Biochemical and biophysical research communications, 2014•Elsevier
Entry of mitochondrial calcium is believed to play an essential role in regulating
bioenergetics and initiating cell death pathways. We have recently described a mouse
model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues
from these animals do not exhibit any marked protection from cell death. Here, we discuss
our findings as well as potential explanations for some of the more unexpected results.
bioenergetics and initiating cell death pathways. We have recently described a mouse
model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues
from these animals do not exhibit any marked protection from cell death. Here, we discuss
our findings as well as potential explanations for some of the more unexpected results.
Abstract
Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results.
Elsevier