[HTML][HTML] Transforming growth factor-β stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
YH Jin, EJ Jeon, QL Li, YH Lee, JK Choi, WJ Kim… - Journal of Biological …, 2004 - ASBMB
The Runt domain transcription factors (RUNXs) play essential roles in normal development
and neoplasias. Genetic analyses of animals and humans have revealed the involvement of
RUNX1 in hematopoiesis and leukemia, RUNX2 in osteogenesis and cleidocranial
dysplasia, and RUNX3 in the development of T-cells and dorsal root ganglion neurons and
in the genesis of gastric cancer. Here we report that RUNX3 is a target of the
acetyltransferase activity of p300. The p300-dependent acetylation of three lysine residues …
and neoplasias. Genetic analyses of animals and humans have revealed the involvement of
RUNX1 in hematopoiesis and leukemia, RUNX2 in osteogenesis and cleidocranial
dysplasia, and RUNX3 in the development of T-cells and dorsal root ganglion neurons and
in the genesis of gastric cancer. Here we report that RUNX3 is a target of the
acetyltransferase activity of p300. The p300-dependent acetylation of three lysine residues …