IL-2 and antigen dose differentially regulate perforin-and FasL-mediated cytolytic activity in antigen specific CD4+ T cells
DM Brown, C Kamperschroer, AM Dilzer… - Cellular …, 2009 - Elsevier
CD4 T cell effectors can promote survival against lethal influenza virus via perforin mediated
cytolytic mechanisms; however, our understanding of how naïve CD4 cells differentiate into
class II restricted killers remains obscure. To address this, TCR Tg CD4 cells were activated
in vitro and examined for their ability to lyse target cells. We found that cytokine polarized
CD4 T cell effectors displayed cytolytic activity with the hierarchy Th0> Th1> Th2. Further, IL-
4 inhibited the generation of cytotoxic CD4 cells. LPS stimulated B cells and bone marrow …
cytolytic mechanisms; however, our understanding of how naïve CD4 cells differentiate into
class II restricted killers remains obscure. To address this, TCR Tg CD4 cells were activated
in vitro and examined for their ability to lyse target cells. We found that cytokine polarized
CD4 T cell effectors displayed cytolytic activity with the hierarchy Th0> Th1> Th2. Further, IL-
4 inhibited the generation of cytotoxic CD4 cells. LPS stimulated B cells and bone marrow …