Shwachman–Diamond syndrome: implications for understanding the molecular basis of leukaemia
Y Dror - Expert reviews in molecular medicine, 2008 - cambridge.org
Y Dror
Expert reviews in molecular medicine, 2008•cambridge.orgInherited bone marrow failure syndromes provide extremely useful genetic models for
understanding leukaemogenesis because the initial genetic defect can be identified and the
risk of leukaemia is very high. Shwachman–Diamond syndrome is one of the most common
inherited bone marrow failure syndromes and an example of such a model. Here, I describe
the malignant features of Shwachman–Diamond syndrome and discuss the potential
molecular mechanisms that can lead to leukaemia.
understanding leukaemogenesis because the initial genetic defect can be identified and the
risk of leukaemia is very high. Shwachman–Diamond syndrome is one of the most common
inherited bone marrow failure syndromes and an example of such a model. Here, I describe
the malignant features of Shwachman–Diamond syndrome and discuss the potential
molecular mechanisms that can lead to leukaemia.
Inherited bone marrow failure syndromes provide extremely useful genetic models for understanding leukaemogenesis because the initial genetic defect can be identified and the risk of leukaemia is very high. Shwachman–Diamond syndrome is one of the most common inherited bone marrow failure syndromes and an example of such a model. Here, I describe the malignant features of Shwachman–Diamond syndrome and discuss the potential molecular mechanisms that can lead to leukaemia.
Cambridge University Press