Design and implementation of the first randomized controlled trial of coenzyme Q10 in children with primary mitochondrial diseases
PW Stacpoole, TJ deGrauw, AS Feigenbaum… - Mitochondrion, 2012 - Elsevier
We report the design and implementation of the first phase 3 trial of CoenzymeQ 10 (CoQ
10) in children with genetic mitochondrial diseases. A novel, rigorous set of eligibility criteria
was established. The trial, which remains open to recruitment, continues to address multiple
challenges to the recruitment of patients, including widely condoned empiric use of CoQ 10
by individuals with proven or suspected mitochondrial disease and skepticism among
professional and lay mitochondrial disease communities about participating in placebo …
10) in children with genetic mitochondrial diseases. A novel, rigorous set of eligibility criteria
was established. The trial, which remains open to recruitment, continues to address multiple
challenges to the recruitment of patients, including widely condoned empiric use of CoQ 10
by individuals with proven or suspected mitochondrial disease and skepticism among
professional and lay mitochondrial disease communities about participating in placebo …