[HTML][HTML] Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis
A Mohapatra, SJ Van Dyken, C Schneider… - Mucosal …, 2016 - Elsevier
Group 2 innate lymphoid cells (ILC2s) have an important role in acute allergic lung
inflammation. Given their distribution and function, lung ILC2s are hypothesized to
coordinate epithelial responses to the external environment; however, how barrier
surveillance is linked to ILC2 activation remains unclear. Here, we demonstrate that alveolar
type II cells are the main source of interleukin (IL)-33 and thymic stromal lymphopoietin
(TSLP) generated in response to chitin or migratory helminths. IL-33 and TSLP …
inflammation. Given their distribution and function, lung ILC2s are hypothesized to
coordinate epithelial responses to the external environment; however, how barrier
surveillance is linked to ILC2 activation remains unclear. Here, we demonstrate that alveolar
type II cells are the main source of interleukin (IL)-33 and thymic stromal lymphopoietin
(TSLP) generated in response to chitin or migratory helminths. IL-33 and TSLP …