Innate lymphoid cells—a proposal for uniform nomenclature

H Spits, D Artis, M Colonna, A Diefenbach… - Nature reviews …, 2013 - nature.com
H Spits, D Artis, M Colonna, A Diefenbach, JP Di Santo, G Eberl, S Koyasu, RM Locksley…
Nature reviews immunology, 2013nature.com
Innate lymphoid cells (ILCs) are a family of developmentally related cells that are involved in
immunity and in tissue development and remodelling. Recent research has identified
several distinct members of this family. Confusingly, many different names have been used
to characterize these newly identified ILC subsets. Here, we propose that ILCs should be
categorized into three groups based on the cytokines that they can produce and the
transcription factors that regulate their development and function.
Abstract
Innate lymphoid cells (ILCs) are a family of developmentally related cells that are involved in immunity and in tissue development and remodelling. Recent research has identified several distinct members of this family. Confusingly, many different names have been used to characterize these newly identified ILC subsets. Here, we propose that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.
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