[CITATION][C] The interleukin-2 receptor
TA Waldman - The Journal of biological chemistry (Print), 1991 - pascal-francis.inist.fr
The interleukin-2 receptor CNRS Inist Pascal-Francis CNRS Pascal and Francis
Bibliographic Databases Simple search Advanced search Search by classification Search
by vocabulary My Account Home > Search results Help Export Export Selection : Selected
items (1) Format : Permanent link CopyPermanent link Copy http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19694847
The interleukin-2 receptor Author WALDMAN, T. A National inst. health, national cancer inst.,
metabolims branch, Bethesda MD 20892, United States Source The Journal of biological …
Bibliographic Databases Simple search Advanced search Search by classification Search
by vocabulary My Account Home > Search results Help Export Export Selection : Selected
items (1) Format : Permanent link CopyPermanent link Copy http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19694847
The interleukin-2 receptor Author WALDMAN, T. A National inst. health, national cancer inst.,
metabolims branch, Bethesda MD 20892, United States Source The Journal of biological …
The interleukin 2 receptor
KA Smith - Annual review of cell biology, 1989 - annualreviews.org
The idea that immune responsiveness and immune memory are determined by
lymphocytotrophic hormones (interleukins) was first introduced when the T cell growth factor,
interleukin 2 (IL-2), was found to bind with high affinity to sites expressed only on antigen-or
lectin-activated T lymphocytes (Robb et al 1981) _ However, inherent in the concept that the
immune system is controlled in a fashion similar to other organ systems is the necessity to
demonstrate that the interleukins and their receptors actually express all of the …
lymphocytotrophic hormones (interleukins) was first introduced when the T cell growth factor,
interleukin 2 (IL-2), was found to bind with high affinity to sites expressed only on antigen-or
lectin-activated T lymphocytes (Robb et al 1981) _ However, inherent in the concept that the
immune system is controlled in a fashion similar to other organ systems is the necessity to
demonstrate that the interleukins and their receptors actually express all of the …
The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia
TA Waldmann, JD White, CK Goldman, L Top, A Grant… - 1993 - ashpublications.org
Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus
human T-cell lymphotrophic virus-I (HTLV-I). It is an aggressive leukemia with an overall
mortality rate of 50% within 5 months; no conventional chemotherapy regimen appears
successful in inducing long-term disease-free survival in ATL patients. However, ATL cells
constitutively express high-affinity interleukin-2 receptors (IL-2Rs) identified by the anti-Tac
monoclonal antibody, whereas normal resting cells do not. To exploit this difference in …
human T-cell lymphotrophic virus-I (HTLV-I). It is an aggressive leukemia with an overall
mortality rate of 50% within 5 months; no conventional chemotherapy regimen appears
successful in inducing long-term disease-free survival in ATL patients. However, ATL cells
constitutively express high-affinity interleukin-2 receptors (IL-2Rs) identified by the anti-Tac
monoclonal antibody, whereas normal resting cells do not. To exploit this difference in …
The multi-subunit interleukin-2 receptor
TA Waldmann - Annual review of biochemistry, 1989 - annualreviews.org
2Abbreviations used in this paper: ADF, ATL-derived factor; AIDS, acquired immune
deficiency syndrome; ATL, adult T-cell leukemia; CAT, chlorophenicol acetyl transferase;
HIV, human immunodeficiency virus; HTLV-I, human T-cell lymphotrophic virus I; IL,
interleukin; LAK, lymphokine-activated killer; LGL, large granular lymphocytes; LTR; long
terminal repeat; NK, natural killer; PHA, phytohemagglutinin; PMA, phorbol myristate
acetate; scm, severe combined immunodeficiency disease; SDS-PAGE, sodium dodecyl …
deficiency syndrome; ATL, adult T-cell leukemia; CAT, chlorophenicol acetyl transferase;
HIV, human immunodeficiency virus; HTLV-I, human T-cell lymphotrophic virus I; IL,
interleukin; LAK, lymphokine-activated killer; LGL, large granular lymphocytes; LTR; long
terminal repeat; NK, natural killer; PHA, phytohemagglutinin; PMA, phorbol myristate
acetate; scm, severe combined immunodeficiency disease; SDS-PAGE, sodium dodecyl …