Monocyte chemotactic protein–induced protein 1 controls allergic airway inflammation by suppressing IL-5–producing TH2 cells through the Notch/Gata3 pathway
Background Asthmatic and allergic inflammation is mediated by TH 2 cytokines (IL-4, IL-5,
and IL-13). Although we have learned much about how TH 2 cells are differentiated, the TH
2 checkpoint mechanisms remain elusive. Objectives In this study we investigate how
monocyte chemotactic protein–induced protein 1 (MCPIP1; encoded by the Zc3h12a gene)
regulates IL-5–producing TH 2 cell differentiation and TH 2-mediated inflammation. Methods
The functions of Zc3h12a−/− CD4 T cells were evaluated by checking the expression of TH 2 …
and IL-13). Although we have learned much about how TH 2 cells are differentiated, the TH
2 checkpoint mechanisms remain elusive. Objectives In this study we investigate how
monocyte chemotactic protein–induced protein 1 (MCPIP1; encoded by the Zc3h12a gene)
regulates IL-5–producing TH 2 cell differentiation and TH 2-mediated inflammation. Methods
The functions of Zc3h12a−/− CD4 T cells were evaluated by checking the expression of TH 2 …