Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures

MJ Gold, F Antignano, TYF Halim, JA Hirota… - Journal of Allergy and …, 2014 - Elsevier
Background Allergic inflammation involves the sensitization of naive CD4+ T cells to
allergens, resulting in a TH 2-skewed inflammatory response. Although antigen presentation
by dendritic cells to T cells in the lymph node is crucial for TH 2 cell development, the innate
signals that initiate adaptive type 2 inflammation and the role of group 2 innate lymphoid
cells (ILC2s) are poorly understood. Objective We sought to investigate the influence of
ILC2s and the route of priming on the development of an adaptive type 2 immune response …