Sleep loss and inflammation

JM Mullington, NS Simpson, HK Meier-Ewert… - Best practice & research …, 2010 - Elsevier
Controlled, experimental studies on the effects of acute sleep loss in humans have shown
that mediators of inflammation are altered by sleep loss. Elevations in these mediators have
been found to occur in healthy, rigorously screened individuals undergoing experimental
vigils of more than 24h, and have also been seen in response to various durations of sleep
restricted to between 25 and 50% of a normal 8h sleep amount. While these altered profiles
represent small changes, such sub-clinical shifts in basal inflammatory cytokines are known …