Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells
Brain, behavior, and immunity, 2012•Elsevier
In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging
from behavior to gene expression. Functional molecular clocks have been described in the
murine spleen and splenic NK cells. The aim of our study was to investigate the existence of
molecular clock mechanisms in other immune cells. Therefore, we measured the circadian
changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-
controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages …
from behavior to gene expression. Functional molecular clocks have been described in the
murine spleen and splenic NK cells. The aim of our study was to investigate the existence of
molecular clock mechanisms in other immune cells. Therefore, we measured the circadian
changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-
controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages …
In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen and splenic NK cells. The aim of our study was to investigate the existence of molecular clock mechanisms in other immune cells. Therefore, we measured the circadian changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages, dendritic cells, and B cells in both mice entrained to a light–dark cycle and under constant environmental conditions. Our study reveals the existence of functional molecular clock mechanisms in splenic macrophages, dendritic cells, and B cells.
Elsevier