Background Inflammation and oxidative stress play critical roles in patients with chronic
obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in
driving the oxidative stress–induced pathology. Objective We sought to determine the effects
of oxidative stress on mitochondrial function in the pathophysiology of airway inflammation
in ozone-exposed mice and human airway smooth muscle (ASM) cells. Methods Mice were
exposed to ozone, and lung inflammation, airway hyperresponsiveness (AHR), and …