[CITATION][C] [3] Toxicological significance of metallothionein
DM Templeton, MG Cherian - Methods in Enzymology, 1991 - Elsevier
12 INTRODUCTION[3] doubt on the importance of MT synthesis in detoxification. 9 The
synthesis of hepatic MT exclusively in free polysomes is indicative of a nonsecretory protein
destined for an intracellular location.~ 0 Together with the absence of significant biliary or
urinary excretion, this suggests that although MT may afford short-term protection, a long-
term role in reducing the body burden of toxins such as cadmium is doubtful. On the other
hand, the obvious protective outcome of MT induction in some cases (including the …
synthesis of hepatic MT exclusively in free polysomes is indicative of a nonsecretory protein
destined for an intracellular location.~ 0 Together with the absence of significant biliary or
urinary excretion, this suggests that although MT may afford short-term protection, a long-
term role in reducing the body burden of toxins such as cadmium is doubtful. On the other
hand, the obvious protective outcome of MT induction in some cases (including the …