Middle‐ear dexamethasone delivery via ultrasound microbubbles attenuates noise‐induced hearing loss
CP Shih, HC Chen, YC Lin, HK Chen… - The …, 2019 - Wiley Online Library
CP Shih, HC Chen, YC Lin, HK Chen, H Wang, CY Kuo, YY Lin, CH Wang
The Laryngoscope, 2019•Wiley Online LibraryObjectives/Hypothesis In this study, we expanded our previous investigation by testing the
efficiency of trans–round window membrane dexamethasone (DEX) delivery mediated by
ultrasound (US)‐aided microbubbles (MBs) and its preventive effects regarding noise
exposure in animal models. Study Design Live animal model. Methods Forty‐two pigmented
male guinea pigs were divided into the following three groups: an US‐MBs (USM) group, in
which the tympanic bulla was filled with DEX and MBs and exposed to US; a round window …
efficiency of trans–round window membrane dexamethasone (DEX) delivery mediated by
ultrasound (US)‐aided microbubbles (MBs) and its preventive effects regarding noise
exposure in animal models. Study Design Live animal model. Methods Forty‐two pigmented
male guinea pigs were divided into the following three groups: an US‐MBs (USM) group, in
which the tympanic bulla was filled with DEX and MBs and exposed to US; a round window …
Objectives/Hypothesis
In this study, we expanded our previous investigation by testing the efficiency of trans–round window membrane dexamethasone (DEX) delivery mediated by ultrasound (US)‐aided microbubbles (MBs) and its preventive effects regarding noise exposure in animal models.
Study Design
Live animal model.
Methods
Forty‐two pigmented male guinea pigs were divided into the following three groups: an US‐MBs (USM) group, in which the tympanic bulla was filled with DEX and MBs and exposed to US; a round window soaking (RWS) group, without the US irradiation; and a control group. The above‐mentioned manipulations were performed 2 hours prior to white noise exposure. The cochlear damage, including auditory threshold shifts, hair cell loss, and expression of cochlear HMGB1, was evaluated.
Results
The enhanced DEX delivery efficiency of the USM group was approximately 2.4× to 11.2× greater than that of the RWS group. After the noise exposure, the RWS group showed significant cochlear protection compared with the control group, and more significant and dominant protective effects were demonstrated in the USM group.
Conclusions
The application of US‐MBs provides a safe and more effective approach than spontaneous diffusion, which is commonly used in clinical practice; thus, this technique holds potential for future inner‐ear drug delivery.
Level of Evidence
NA
Laryngoscope, 129:1907–1914, 2019
Wiley Online Library