[HTML][HTML] Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis
T Shibasaki, Y Sunaga, K Fujimoto, Y Kashima… - Journal of Biological …, 2004 - ASBMB
ATP, cAMP, and Ca 2+ are the major signals in the regulation of insulin granule exocytosis
in pancreatic β cells. The sensors and regulators of these signals have been characterized
individually. The ATP-sensitive K+ channel, acting as the ATP sensor, couples cell
metabolism to membrane potential. cAMP-GEFII, acting as a cAMP sensor, mediates cAMP-
dependent, protein kinase A-independent exocytosis, which requires interaction with both
Piccolo as a Ca 2+ sensor and Rim2 as a Rab3 effector. l-type voltage-dependent Ca 2+ …
in pancreatic β cells. The sensors and regulators of these signals have been characterized
individually. The ATP-sensitive K+ channel, acting as the ATP sensor, couples cell
metabolism to membrane potential. cAMP-GEFII, acting as a cAMP sensor, mediates cAMP-
dependent, protein kinase A-independent exocytosis, which requires interaction with both
Piccolo as a Ca 2+ sensor and Rim2 as a Rab3 effector. l-type voltage-dependent Ca 2+ …