[HTML][HTML] Endogenous SNAP-25 regulates native voltage-gated calcium channels in glutamatergic neurons
SB Condliffe, I Corradini, D Pozzi, C Verderio… - Journal of biological …, 2010 - ASBMB
In addition to its primary role as a fundamental component of the SNARE complex, SNAP-25
also modulates voltage-gated calcium channels (VGCCs) in various overexpression
systems. Although these studies suggest a potential negative regulatory role of SNAP-25 on
VGCC activity, the effects of endogenous SNAP-25 on native VGCC function in neurons are
unclear. In the present study, we investigated the VGCC properties of cultured glutamatergic
and GABAergic rat hippocampal neurons. Glutamatergic currents were dominated by P/Q …
also modulates voltage-gated calcium channels (VGCCs) in various overexpression
systems. Although these studies suggest a potential negative regulatory role of SNAP-25 on
VGCC activity, the effects of endogenous SNAP-25 on native VGCC function in neurons are
unclear. In the present study, we investigated the VGCC properties of cultured glutamatergic
and GABAergic rat hippocampal neurons. Glutamatergic currents were dominated by P/Q …