[HTML][HTML] Analysis of the synaptotagmin family during reconstituted membrane fusion: uncovering a class of inhibitory isoforms
A Bhalla, MC Chicka, ER Chapman - Journal of biological chemistry, 2008 - ASBMB
Ca 2+-triggered exocytosis in neurons and neuroendocrine cells is regulated by the Ca 2+-
binding protein synaptotagmin (syt) I. Sixteen additional isoforms of syt have been identified,
but little is known concerning their biochemical or functional properties. Here, we assessed
the abilities of fourteen syt isoforms to directly regulate SNARE (soluble N-ethylmaleimide-
sensitive factor (NSF) attachment protein receptor)-catalyzed membrane fusion. One group
of isoforms stimulated neuronal SNARE-mediated fusion in response to Ca 2+, while …
binding protein synaptotagmin (syt) I. Sixteen additional isoforms of syt have been identified,
but little is known concerning their biochemical or functional properties. Here, we assessed
the abilities of fourteen syt isoforms to directly regulate SNARE (soluble N-ethylmaleimide-
sensitive factor (NSF) attachment protein receptor)-catalyzed membrane fusion. One group
of isoforms stimulated neuronal SNARE-mediated fusion in response to Ca 2+, while …