Different immune cells mediate mechanical pain hypersensitivity in male and female mice
Nature neuroscience, 2015•nature.com
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling
is essential for chronic pain hypersensitivity. Using multiple approaches, we found that
microglia are not required for mechanical pain hypersensitivity in female mice; female mice
achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T
lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for
females in pain research.
is essential for chronic pain hypersensitivity. Using multiple approaches, we found that
microglia are not required for mechanical pain hypersensitivity in female mice; female mice
achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T
lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for
females in pain research.
Abstract
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
nature.com