Minocycline protects retinal ganglion cells after optic nerve crush injury in mice by delaying autophagy and upregulating nuclear factor-κB2

X Jiao, Y Peng, L Yang - Chinese medical journal, 2014 - journals.lww.com
Background Currently, no medicine is available that can prevent or treat neural damage
associated with optic nerve injury. Minocycline is recently reported to have a neuroprotective
function. The aims of this study were to exarmine the neuroprotective effect of minocycline
on retinal ganglion cells (RGCs) and determine its underlying mechanisms, using a mouse
model of optic nerve crush (ONC). Methods ONC was performed in the left eye of adult male
mice, and the mice were randomly divided into minocycline-treated group and saline-treated …