[HTML][HTML] Specific contactin N-glycans are implicated in neurofascin binding and autoimmune targeting in peripheral neuropathies

M Labasque, B Hivert, G Nogales-Gadea… - Journal of Biological …, 2014 - ASBMB
Cell adhesion molecules (CAMs) play a crucial role in the formation of the nodes of Ranvier
and in the rapid propagation of the nerve impulses along myelinated axons. These CAMs
are the targets of autoimmunity in inflammatory neuropathies. We recently showed that a
subgroup of patients with aggressive chronic inflammatory demyelinating
polyradiculoneuropathy (CIDP) shows autoantibodies to contactin (1). The complex of
contactin· Caspr· neurofascin-155 (NF155) enables the formation of paranodal junctions …