Peptidylarginine deiminases: physiological function, interaction with chemokines and role in pathology
EAV Moelants, A Mortier, J Van Damme… - Drug Discovery Today …, 2012 - Elsevier
Chemokines are low molecular mass chemotactic proteins that signal through G protein-
coupled receptors (GPCR). Chemokine activity is regulated at multiple levels including
posttranslational modification (PTM). Proteolytic processing of chemokines at the NH2-
terminus by metalloproteases and serine proteases has been reported to severely affect
chemokine activity. In addition, COOH-terminal truncation and glycosylation has been
detected on some chemokines. Recently, the inflammatory chemokines CXCL8 and …
coupled receptors (GPCR). Chemokine activity is regulated at multiple levels including
posttranslational modification (PTM). Proteolytic processing of chemokines at the NH2-
terminus by metalloproteases and serine proteases has been reported to severely affect
chemokine activity. In addition, COOH-terminal truncation and glycosylation has been
detected on some chemokines. Recently, the inflammatory chemokines CXCL8 and …