Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies
JK O'neill, D Baker, AN Davidson, SJ Allen… - Journal of …, 1993 - Elsevier
Chronic relapsing experimental allergic encephalomyelitis (CREAE) was induced in Biozzi
AB/H (H-2 dq1) mice by active sensitization with spinal cord antigens. A single ip injection of
CD8-depleting (YTS169. 4) monoclonal antibody (mAb) failed to affect the clinical course of
CREAE when administered prior to and during the onset of both the initial clinical and
subsequent relapse phase of the disease. By ccontrast similar treatment with both CD4-
depleting (YTS191. 1) or CD4-blocking/non-depleting (YTS177. 9) mAb significantly …
AB/H (H-2 dq1) mice by active sensitization with spinal cord antigens. A single ip injection of
CD8-depleting (YTS169. 4) monoclonal antibody (mAb) failed to affect the clinical course of
CREAE when administered prior to and during the onset of both the initial clinical and
subsequent relapse phase of the disease. By ccontrast similar treatment with both CD4-
depleting (YTS191. 1) or CD4-blocking/non-depleting (YTS177. 9) mAb significantly …