Autoimmunity and type I diabetes
JF Bach - Trends in Endocrinology & Metabolism, 1997 - cell.com
JF Bach
Trends in Endocrinology & Metabolism, 1997•cell.comInsulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease. The
effector mechanisms essentially involve cytokine-mediated inflammation ultimately leading
to β-cell destruction. Several candidate autoantigens have been delineated for both the
pathogenic T-cell response and the nonpathogenic antibody response used for disease
prediction. Because of antigen spreading, it is not yet clear which of these antigens are
involved in the triggering of the autoimmune response. In any case, this TH1 autoimmune …
effector mechanisms essentially involve cytokine-mediated inflammation ultimately leading
to β-cell destruction. Several candidate autoantigens have been delineated for both the
pathogenic T-cell response and the nonpathogenic antibody response used for disease
prediction. Because of antigen spreading, it is not yet clear which of these antigens are
involved in the triggering of the autoimmune response. In any case, this TH1 autoimmune …
Abstract
Insulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease. The effector mechanisms essentially involve cytokine-mediated inflammation ultimately leading to β-cell destruction. Several candidate autoantigens have been delineated for both the pathogenic T-cell response and the nonpathogenic antibody response used for disease prediction. Because of antigen spreading, it is not yet clear which of these antigens are involved in the triggering of the autoimmune response. In any case, this TH1 autoimmune response is amplified and perpetuated by an immune dysregulation involving TH2 cells. Both effector and regulatory mechanisms are placed under the tight control of major histocompatibility complex (MHC) and non-MHC genes. (Trends Endocrinol Metab 1997; 8:71–74). © 1997, Elsevier Science Inc.
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