Prolonged Measles Virus Shedding in Human Immunodeficiency Virus—Infected Children, Detected by Reverse Transcriptase—Polymerase Chain Reaction
The Journal of infectious diseases, 2001•academic.oup.com
A reverse transcriptase—polymerase chain reaction assay was used to detect measles virus
RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from
Zambian children during hospitalization and∼ 1–2 months after discharge. Of 47 children,
29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus
RNA in⩾ 1 specimen obtained 30–61 days after rash onset. Ten (90.9%) of 11 human
immunodeficiency virus (HIV)—infected children had prolonged measles virus shedding …
RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from
Zambian children during hospitalization and∼ 1–2 months after discharge. Of 47 children,
29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus
RNA in⩾ 1 specimen obtained 30–61 days after rash onset. Ten (90.9%) of 11 human
immunodeficiency virus (HIV)—infected children had prolonged measles virus shedding …
Abstract
A reverse transcriptase—polymerase chain reaction assay was used to detect measles virus RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from Zambian children during hospitalization and ∼1–2 months after discharge. Of 47 children, 29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus RNA in ⩾1 specimen obtained 30–61 days after rash onset. Ten (90.9%) of 11 human immunodeficiency virus (HIV)—infected children had prolonged measles virus shedding, compared with 19 (52.8%) of 36 HIV-uninfected children (P = .02). Prolonged measles virus shedding did not correlate with levels of measles virus—specific antibody. HIV-infected children with measles may have a prolonged infectious period that potentially enhances measles virus transmission and hinders measles control.
Oxford University Press