Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution
MA SIMON, LV CHALIFOUX… - AIDS research and human …, 1992 - liebertpub.com
MA SIMON, LV CHALIFOUX, DJ RINGLER
AIDS research and human retroviruses, 1992•liebertpub.comSince the original isolation of simian immunodeficiency virus (SIV) from a macaque with an
AIDS-like disease, numerous studies have demonstrated the close biologic and genetic
relationship of the SIVs to the HIVs. Probably most important, the clinical spectrum of
disease associated with SIVmac/SIVsmm infection in rhesus monkeys is strikingly similar to
AIDS in HIV-1-infected human beings. Herein are summarized the pathologic features of
SIVmac-induced disease in a cohort of rhesus monkeys, with special reference to the role of …
AIDS-like disease, numerous studies have demonstrated the close biologic and genetic
relationship of the SIVs to the HIVs. Probably most important, the clinical spectrum of
disease associated with SIVmac/SIVsmm infection in rhesus monkeys is strikingly similar to
AIDS in HIV-1-infected human beings. Herein are summarized the pathologic features of
SIVmac-induced disease in a cohort of rhesus monkeys, with special reference to the role of …
Since the original isolation of simian immunodeficiency virus (SIV) from a macaque with an AIDS-like disease, numerous studies have demonstrated the close biologic and genetic relationship of the SIVs to the HIVs. Probably most important, the clinical spectrum of disease associated with SIVmac/SIVsmm infection in rhesus monkeys is strikingly similar to AIDS in HIV-1-infected human beings. Herein are summarized the pathologic features of SIVmac-induced disease in a cohort of rhesus monkeys, with special reference to the role of infected macrophages in the development of AIDS-related manifestations.
Mary Ann Liebert