Genetic polymorphisms in Cytochrome P 4501B1 and susceptibility to idiopathic preterm labor in North Indian population
MD Mustafa, T Sharma, BD Banerjee, M Phil… - Clinical …, 2013 - Elsevier
MD Mustafa, T Sharma, BD Banerjee, M Phil, RS Ahmed, AK Tripathi, K Guleria
Clinical Biochemistry, 2013•ElsevierObjective The etiology of preterm labor (PTL) is still unknown, but it may be related to a
possible genetic predisposition together with involvement of environmental factors. We
investigated the relation between PTL and polymorphisms in Cytochrome P4501B1
(CYP1B1) gene, which is involved in the metabolism of a wide range of environmental toxins
and hormones. Design and methods Three hundred (n= 300) cases of PTL and equal
number of subjects of full term labor (FTL), after excluding all the known risk factors for PTL …
possible genetic predisposition together with involvement of environmental factors. We
investigated the relation between PTL and polymorphisms in Cytochrome P4501B1
(CYP1B1) gene, which is involved in the metabolism of a wide range of environmental toxins
and hormones. Design and methods Three hundred (n= 300) cases of PTL and equal
number of subjects of full term labor (FTL), after excluding all the known risk factors for PTL …
Objective
The etiology of preterm labor (PTL) is still unknown, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We investigated the relation between PTL and polymorphisms in Cytochrome P4501B1 (CYP1B1) gene, which is involved in the metabolism of a wide range of environmental toxins and hormones.
Design and methods
Three hundred (n = 300) cases of PTL and equal number of subjects of full term labor (FTL), after excluding all the known risk factors for PTL were included in the study. A two step allele specific PCR was performed for polymorphic analysis of CYP1B1 gene.
Results
The homozygous variant genotype of CYP1B1*2 (OR = 2.97, 95%CI = 1.08–8.08, p = 0.033) and heterozygous variant of CYP1B1*3 (OR = 2.57, 95%CI = 1.88–3.63, p = 0.001), and CYP1B1*7 (OR = 2.59, 95%CI = 1.85–3.62, p = 0.001) were found to be significantly higher in PTL cases as compared to FTL.
Conclusions
The present study demonstrates the possible association of homozygous variant of CYP1B1*2 and heterozygous variant of CYP1B1*3 and CYP1B1*7 genes with the increased risk of PTL.
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