Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short …
A Conde-Agudelo, R Romero, E Da Fonseca… - American journal of …, 2018 - Elsevier
Background An indirect comparison meta-analysis published in 2013 reported that both
vaginal progesterone and cerclage are equally efficacious for preventing preterm birth and
adverse perinatal outcomes in women with a singleton gestation, previous spontaneous
preterm birth, and a sonographic short cervix. The efficacy of vaginal progesterone has been
challenged after publication of the OPPTIMUM study. However, this has been resolved by an
individual patient-data meta-analysis (Am J Obstet Gynecol. 2018; 218: 161-180). Objective …
vaginal progesterone and cerclage are equally efficacious for preventing preterm birth and
adverse perinatal outcomes in women with a singleton gestation, previous spontaneous
preterm birth, and a sonographic short cervix. The efficacy of vaginal progesterone has been
challenged after publication of the OPPTIMUM study. However, this has been resolved by an
individual patient-data meta-analysis (Am J Obstet Gynecol. 2018; 218: 161-180). Objective …