Identification of a gene expression signature in peripheral blood of multiple sclerosis patients treated with disease-modifying therapies
C Cordiglieri, F Baggi, P Bernasconi, D Kapetis… - Clinical …, 2016 - Elsevier
Multiple Sclerosis (MS) is an inflammatory disease with neurodegenerative alterations,
ultimately progressing to neurological handicap. Therapies are effective in counteracting
inflammation but not neurodegeneration. Biomarkers predicting disease course or treatment
response are lacking. We investigated whether altered gene and protein expression profiles
were detectable in the peripheral blood of 78 relapsing remitting MS (RR-MS) patients
treated by disease-modifying therapies. A discovery/validation study on RR-MS responsive …
ultimately progressing to neurological handicap. Therapies are effective in counteracting
inflammation but not neurodegeneration. Biomarkers predicting disease course or treatment
response are lacking. We investigated whether altered gene and protein expression profiles
were detectable in the peripheral blood of 78 relapsing remitting MS (RR-MS) patients
treated by disease-modifying therapies. A discovery/validation study on RR-MS responsive …
