Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions
E Ivanova, CW Yee, R Baldoni Jr… - Experimental eye …, 2016 - Elsevier
In retinal degenerative disease (RD), the diminished light signal from dying photoreceptors
has been considered the sole cause of visual impairment. Recent studies show a 10-fold
increase in spontaneous activity in the RD network, challenging this paradigm. This aberrant
activity forms a new barrier for the light signal, and not only exacerbates the loss of vision,
but also may stand in the way of visual restoration. This activity originates in AII amacrine
cells and relies on excessive activation of gap junctions. However, it remains unclear …
has been considered the sole cause of visual impairment. Recent studies show a 10-fold
increase in spontaneous activity in the RD network, challenging this paradigm. This aberrant
activity forms a new barrier for the light signal, and not only exacerbates the loss of vision,
but also may stand in the way of visual restoration. This activity originates in AII amacrine
cells and relies on excessive activation of gap junctions. However, it remains unclear …
