[HTML][HTML] Genetic ablation of TRPV1 exacerbates pressure overload-induced cardiac hypertrophy

B Zhong, J Rubinstein, S Ma, DH Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
B Zhong, J Rubinstein, S Ma, DH Wang
Biomedicine & Pharmacotherapy, 2018Elsevier
Transient receptor potential vanilloid 1 (TRPV1) channels expressed in sensory nerves may
regulate vascular tone and cardiovascular function via their anti-inflammatory effects by
releasing neuropeptide calcitonin gene-related peptide (CGRP). Inflammation plays a role in
the progression of cardiac hypertrophy and TRPV1 activation may be key to cardiac
inflammatory processes. The aim of this study was to test the hypothesis that TRPV1
modulates inflammatory processes to protect the heart from pressure overload-induced …
Abstract
Transient receptor potential vanilloid 1 (TRPV1) channels expressed in sensory nerves may regulate vascular tone and cardiovascular function via their anti-inflammatory effects by releasing neuropeptide calcitonin gene-related peptide (CGRP). Inflammation plays a role in the progression of cardiac hypertrophy and TRPV1 activation may be key to cardiac inflammatory processes. The aim of this study was to test the hypothesis that TRPV1 modulates inflammatory processes to protect the heart from pressure overload-induced hypertrophy and inflammatory responses. Trpv1 knockout (Trpv1−/−) and wild-type (WT) mice were subjected to transverse aortic constriction (TAC) or sham operation. Four weeks after TAC, WT and Trpv1-/- mice had developed left ventricular (LV) hypertrophy with increased LV mass, fibrosis and infiltration of macrophages as well as increased secretion of tumor necrosis factor α, interleukin-6 from cardiac tissue (all P < 0.05), those were higher in Trpv1-/- than in WT mice with TAC (all P < 0.05). In addition, decreases of LV ejection fraction and fractional shortening were greater in Trpv1-/- than in WT mice (both P < 0.05). Moreover, atrial natriuretic peptide level was greater in Trpv1-/- than in WT mice with TAC (P < 0.05). Compared to sham control, TAC procedure significantly increased cardiac TRPV1 expression and CGRP release in WT mice (both P < 0.05), but not in Trpv1-/- mice. These results demonstrate that Trpv1 gene deletion results in excessive inflammation, exaggerates cardiac hypertrophy, and deteriorates cardiac function after TAC, which may be due to abnormal cardiac remodeling and decreased CGRP in the absence of TRPV1.
Elsevier