[HTML][HTML] Lipopolysaccharide primes the NALP3 inflammasome by inhibiting its ubiquitination and degradation mediated by the SCFFBXL2 E3 ligase
The inflammasome is a multiprotein complex that augments the proinflammatory response
by increasing the generation and cellular release of key cytokines. Specifically, the NALP3
inflammasome requires two-step signaling, priming and activation, to be functional to
release the proinflammatory cytokines IL-1β and IL-18. The priming process, through
unknown mechanisms, increases the protein levels of NALP3 and pro-IL-1β in cells. Here
we show that LPS increases the NALP3 protein lifespan without significantly altering steady …
by increasing the generation and cellular release of key cytokines. Specifically, the NALP3
inflammasome requires two-step signaling, priming and activation, to be functional to
release the proinflammatory cytokines IL-1β and IL-18. The priming process, through
unknown mechanisms, increases the protein levels of NALP3 and pro-IL-1β in cells. Here
we show that LPS increases the NALP3 protein lifespan without significantly altering steady …