Innate response activator B cells: origins and functions
BG Chousterman, FK Swirski - International immunology, 2015 - academic.oup.com
BG Chousterman, FK Swirski
International immunology, 2015•academic.oup.comInnate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the
growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models
of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate
to the spleen or lung, and differentiate to IRA B cells that then contribute to the host response
by amplifying inflammation and producing polyreactive IgM. In atherosclerosis, IRA B cells
accumulate in the spleen, where they promote extramedullary hematopoiesis and activate …
growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models
of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate
to the spleen or lung, and differentiate to IRA B cells that then contribute to the host response
by amplifying inflammation and producing polyreactive IgM. In atherosclerosis, IRA B cells
accumulate in the spleen, where they promote extramedullary hematopoiesis and activate …
Abstract
Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate to the spleen or lung, and differentiate to IRA B cells that then contribute to the host response by amplifying inflammation and producing polyreactive IgM. In atherosclerosis, IRA B cells accumulate in the spleen, where they promote extramedullary hematopoiesis and activate classical dendritic cells. In this review, we focus on the ontogeny and function of IRA B cells in acute and chronic inflammation.
Oxford University Press