The ubiquitin code
D Komander, M Rape - Annual review of biochemistry, 2012 - annualreviews.org
Annual review of biochemistry, 2012•annualreviews.org
The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a
single moiety or in the form of polymeric chains in which successive ubiquitin molecules are
connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin
modifications adopt distinct conformations and lead to different outcomes in cells. Here, we
discuss the structure, assembly, and function of this ubiquitin code.
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a
single moiety or in the form of polymeric chains in which successive ubiquitin molecules are
connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin
modifications adopt distinct conformations and lead to different outcomes in cells. Here, we
discuss the structure, assembly, and function of this ubiquitin code.
The posttranslational modification with ubiquitin, a process referred to as ubiquitylation, controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a single moiety or in the form of polymeric chains in which successive ubiquitin molecules are connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin modifications adopt distinct conformations and lead to different outcomes in cells. Here, we discuss the structure, assembly, and function of this ubiquitin code.
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