Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis
I Ackers, C Szymanski, KJ Duckett, LA Consitt… - Cardiovascular …, 2018 - Elsevier
Background and aims Wnt5a is a highly studied member of the Wnt family and recently has
been implicated in the pathogenesis of atherosclerosis, but its precise role is unknown.
Foam cell development is a critical process to atherosclerotic plaque formation. In the
present study, we investigated the role of noncanonical Wnt5a signaling in the development
of foam cells. Methods Human carotid atherosclerotic tissue and THP-1-derived
macrophages were used to investigate the contribution of Wnt5a signaling in the formation …
been implicated in the pathogenesis of atherosclerosis, but its precise role is unknown.
Foam cell development is a critical process to atherosclerotic plaque formation. In the
present study, we investigated the role of noncanonical Wnt5a signaling in the development
of foam cells. Methods Human carotid atherosclerotic tissue and THP-1-derived
macrophages were used to investigate the contribution of Wnt5a signaling in the formation …