Expression profiling of fibroblasts in chronic and acute disease models reveals novel pathways in kidney fibrosis
AY Higashi, BJ Aronow… - Journal of the American …, 2019 - journals.lww.com
Background Renal interstitial fibrosis results from activation and proliferation of fibroblasts to
myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of
normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a
process that includes a decrease in the number of myofibroblasts in the interstitium and
degradation of the accumulated extracellular matrix, leaving little evidence of prior injury.
Methods To investigate whether activated fibroblasts demonstrate changes in gene …
myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of
normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a
process that includes a decrease in the number of myofibroblasts in the interstitium and
degradation of the accumulated extracellular matrix, leaving little evidence of prior injury.
Methods To investigate whether activated fibroblasts demonstrate changes in gene …